Yield

8 servings

Prep Time

15 minutes

Cook Time

30–35 minutes

Total Time

45–50 minutes

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Ingredients

Base

• 1 can (16.3 oz) refrigerated buttermilk biscuits (8 biscuits)
• 1 jar (14 oz) pizza sauce

Cheese

• 3 cups shredded mozzarella cheese, divided

Pizza Toppings

• 1 cup pepperoni slices
• ½ pound cooked ground beef or Italian sausage
• 1 cup sliced mushrooms
• ½ cup sliced black olives
• ½ cup diced green bell pepper
• ¼ cup diced onion

Seasoning

• 2 tablespoons grated Parmesan cheese
• 1 teaspoon Italian seasoning
• ½ teaspoon garlic powder

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Equipment

• 9×13-inch baking dish
• Mixing bowl
• Oven

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Instructions

Step 1: Preheat Oven

Preheat oven to 375°F (190°C).

Lightly grease a 9×13-inch baking dish.

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Step 2: Prepare Biscuit Dough

Cut each biscuit into 6–8 bite-sized pieces.

Place biscuit pieces into a large mixing bowl.

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Step 3: Mix Filling

Add:

• Pizza sauce
• Cooked ground beef
• Mushrooms
• Olives
• Bell peppers
• Onions
• 1½ cups mozzarella

Mix until biscuit pieces are evenly coated.

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Step 4: Assemble

Pour mixture into prepared baking dish.

Spread evenly.

Top with:

• Remaining mozzarella cheese
• Pepperoni slices
• Parmesan cheese
• Italian seasoning
• Garlic powder

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Step 5: Bake

Bake for 30–35 minutes.

The casserole is done when:

• Biscuits are fully cooked inside
• Cheese is melted and golden
• Internal temperature reaches 165°F (74°C)

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Step 6: Rest

Let rest for 5–10 minutes before serving.

Slice and serve.

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Nutrition Information

Per Serving (1/8 of casserole)

Approximate values:

Values vary depending on biscuit brand and toppings used.

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Allergen Information

Contains:

• Wheat/Gluten
• Milk/Dairy

May contain:

• Soy (depending on biscuit and sauce brands)

Can be made:

• Gluten-free with GF biscuit dough
• Lower-fat using turkey pepperoni and reduced-fat cheese

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Storage

Refrigerator

Store in airtight container up to 4 days.

Freezer

Freeze up to 2 months.

Reheating

• Oven: 350°F for 15–20 minutes
• Microwave: 1–2 minutes per serving

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Variations

Meat Lover’s

Add:

• Bacon
• Sausage
• Ham
• Pepperoni

Supreme

Add:

• Green peppers
• Mushrooms
• Onions
• Olives
• Sausage

Veggie

Add:

• Spinach
• Tomatoes
• Bell peppers
• Mushrooms
• Olives

Hawaiian

Add:

• Ham
• Pineapple

Buffalo Chicken

Replace pizza sauce with buffalo sauce and use shredded chicken.

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Frequently Asked Questions (Q&A)

Q: Can I use crescent roll dough instead of biscuits?

Yes. Biscuit dough gives a fluffier, pull-apart texture, while crescent dough produces a softer casserole.

Q: How do I know the biscuits are cooked through?

Insert a knife into the center. The dough should not appear wet or gummy.

Q: Can I make it ahead of time?

Yes. Assemble up to 24 hours ahead and refrigerate. Bake when ready.

Q: Can I freeze before baking?

Yes. Wrap tightly and freeze for up to 2 months. Thaw overnight before baking.

Q: What cheese works best?

Mozzarella is classic, but blends of mozzarella, provolone, Monterey Jack, and cheddar work well.

Q: Why is my casserole watery?

Excess moisture from vegetables or sauce can cause this. Pre-cook mushrooms and drain meats thoroughly.

Q: Can I make it low-carb?

Use a low-carb dough substitute such as cauliflower pizza dough pieces or keto biscuit dough.

Q: What sides go well with this?

• Caesar salad
• Garlic bread
• Roasted vegetables
• Antipasto salad

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Serving Suggestions

Serve with:

• Fresh green salad
• Garlic knots
• Marinara dipping sauce
• Parmesan cheese
• Crushed red pepper flakes